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Study of in vivo toxicity of selected compounds with the implementation of the invertebrate model Galleria mellonella
Turinová, Veronika ; Konečná, Klára (advisor) ; Janďourek, Ondřej (referee)
6 ABSTRACT Charles university, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Pharmacy Author: Veronika Záveská Supervisor: RNDr. Klára Konečná, Ph.D. Title of thesis: Study of in vivo toxicity of selected compounds with the implementation of the invertebrate model Galleria mellonella Background: The aim of this diploma thesis was to monitor the influence of the weight of the larvae, or rather its developmental stage, on the results after the administration of selected doses of DMSO. In the experimental work, the toxic impact of DMSO on larvae was evaluated not only from the point of view of mortality. Much attention was also paid to the characteristic features that are commonly observed during tests on Galleria mellonella larvae, such as the degree of melanization, the impact on activity and cocoon formation. Methods: For individual experiments, three test groups of six individuals each were created based on weight, one group of larvae weighing 250 ± 10 mg, the second group weighing 350 ± 15 mg and the third group weighing 450 ± 15 mg. Using a Hamilton syringe, a volume of 10 µl of the test solution with the appropriate concentration of DMSO was administered to each larva directly into the haemocoel through the last left proleg. The administered doses...
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Analysis of drug administration by nurses in health facility XI
Altmannová, Tereza ; Doseděl, Martin (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XI Author: Tereza Altmannová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are intrinsically linked to the practice of the medical profession. They can occur at several levels - prescription, drug preparation, dispensation, administration, and subsequent use of the drug by the patient. Nurses play an important role in the process of the drug administration in a hospital setting. Because of the occurrenceof medication errors and the consequent inability to achieve desired health outcomes, efforts are nowadays made to detect and minimize them. The aim of this study was to detect and analyze medication errors occurring during drug administration by nurses in a healthcare facility in South Bohemia. Methodology: The study is a part of a multi-year project involving the Faculty of Pharmacy of Charles University. The methodology is based on an observational study. The data collection took place in April 2022. Three hospital wards were assigned for the observation, where morning, midday and evening drug administration was monitored for three consecutive days. Data were recorded on a pre- generated form based on the...
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Analysis of drug administration by nurses in health facility II
Bančíková, Natalie ; Malý, Josef (advisor) ; Horký, Pavel (referee)
Analysis of drug administration by nurses in a health facility II Author: Natalie Blizňáková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are one of the main causes of adverse events that can lead to damage to health or death of the patient. The aim of this work was to analyze the administration of drugs by nurses to patients hospitalized in one health facility providing inpatient care in the South Bohemian region with emphasis on medication errors and their prevention. Methodology: This diploma thesis is part of a long-term observation-intervention project, which takes place in the years 2020-2023. The surgical, internal medicine and aftercare departments were observed. Data collection for this work took place in the form of direct observation by a trained team of pharmacists and nurses, from June 28 to July 1 and from August 23 to August 26, 2021, for three consecutive days. The following data were collected: patient data (e.g., age; gender; all drugs used), data on the nurse administering the drugs (e.g., length of practice and education) and data on the actual administration of drugs (e.g., method of patient identification; nurse...
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Analysis of drug administration by nurses in health facility XV.
Chudovská, Denisa ; Malý, Josef (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XV. Author: Denisa Chudovská Tutor: doc. PharmDr. Josef Malý. Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: The role of nurses is key not only in the occurrence of medication errors, but also in their prevention. The aim of the thesis was to analyze the administration of medications by nurses to patients hospitalized in three departments within a healthcare facility and to compare the results with the first year of monitoring in the given hospital. Methods: This is an observational-interventional study. The data collection method was passive observation. The study included patients in surgical, internal medicine, and post-care departments within one of the four hospitals in the Czech Republic. Data collection took place over three consecutive days. The collected data encompassed information: about the patient, the nurse and medication name, strength, preparation, administration, usage verification. The analysis of obtained data was performed using a Summary of Product Characteristics and relevant information sources available at the Pharmaceutical Faculty of Charles University in Hradec Králové. To assess the impact of...
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Analysis of drug administration by nurses in health facility VIII
Vaclaviková, Iveta ; Malý, Josef (advisor) ; Šorf, Aleš (referee)
Author: Iveta Vaclaviková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Medication errors contribute significantly to the occurrence of adverse events that can impact patient health. The aim of this thesis was to analyze the administration of drugs to patients hospitalized by nurses in one of four studied health facilities in the South Bohemia region in the surgical, internal medicine and aftercare wards. Methods: This diploma thesis is part of an observational-interventional study, in years 2020- 2023. Observations took place in internal medicine, surgery and aftercare wards. Collection of data was held from 23th May to 26th May 2022 by a multidisciplinary team made up of a pharmacist and a nurse by direct observation method. These following data were collected: information about pacient (e.g., gender, age, and any medications taken), information about the nurse by whom the medications were administered (e.g., age, years of experience, highest educational attainment), and information recorded during the actual administration of the medications (e.g. nurse compliance with hygiene requirements; patient identification; checking originality of the drug; whether the...
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Analysis of drug administration by nurses in health facility VII
Polášová, Barbora ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee)
Analysis of drug administration by nurses in health facility VII Author: Barbora Polášová Tutor: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Medication errors can cause a great risk in administration of drugs to health of patients. The aim of this thesis was to analyze the administration of drugs by nurses to patients hospitalized in three different wards in a medical facility in the South Bohemian region. Mathods: This thesis is a part of an observational-interventional study, ongoing in 2020-2023. Collection of data was held in one of South Bohemian hospitals in the surgery, internal medicine and aftercare wards between 17th May and 19th May. Data were collected by a direct observation method by a trained multidisciplinary team consisting of pharmacists and nurses. The observed parameters were: information about patient (e.g. gender, age and used medications), information about nurse (e.g. gender, age, length of practice) and drug administration's data (e.g. hygiene, patient identification, correct medication, right dose and strength, right patient, correct time, way of drug's manipulation, used drink for wash down, time interval from food). All collected data were anonymized,...
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Analysis of drug administration by nurses in health facility XIV
Newaldová, Sandra ; Doseděl, Martin (advisor) ; Rejmanová, Anna (referee)
Analysis of drug administration by nurses in health facility XIV. Author: Sandra Newaldová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Medication errors are one of the causes of adverse events in healthcare facilities, leading to patient endangerment or harm. A study looking at this issue reports that the most common errors occur when a nurse administers medicines in a healthcare facility. Aim: The aim of the thesis is to monitor medication errors of nurses during the preparation and administration of medication to patients and to analyse the prevalence of medication errors, determine their type, their relationship to other influencing factors, and their severity with respect to the patient's condition. Methods: Prospective observational study with direct observation method, conducted in a specialized medical rehabilitation facility. The study included two pre- and post- intervention phases in which nurses' medication and procedural errors were monitored, analysed and evaluated. Observations were conducted in each phase over three days each time during morning, midday and evening administration. The results were analysed in programs Microsoft Excel and Wolfram Mathematica. Results: The...
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Analysis of drug administration by nurses in health facility IX
Blažková, Kateřina ; Doseděl, Martin (advisor) ; Košťálová, Barbora (referee)
Analysis of drug administration by nurses in a health facility X Author: Kateřina Blažková Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy, in Hradec Králové, Charles University Introduction and aims: Currently, patients are treated primarily through pharmacotherapy. As a consequence of this fact, an ever-increasing incidence of medication errors can be expected. Medication errors and the resulting adverse events can have adverse consequences for the patient and, consequently, for the entire healthcare system. The aim of this study was to analyse the whole process of drug administration by nurses in inpatient wards in a South Bohemian hospital. Methods: This thesis is part of an ongoing research project involving the Faculty of Pharmacy of Charles University. The first data collection took place in 2021, followed by interventions towards nurses, doctors and hospital management. The data collection for this work was similarly conducted using the direct observation method for three consecutive days from 2 to 5 May 2022. Using a trained multidisciplinary team consisting of a pharmacist and a nurse, the internal medicine, surgery and aftercare departments were observed. Morning, midday and evening medication administration was observed in each ward....
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Analysis of drug administration by nurses in health facility XI
Altmannová, Tereza ; Doseděl, Martin (advisor) ; Dvořáčková, Simona (referee)
Analysis of drug administration by nurses in health facility XI Author: Tereza Altmannová Tutor: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are intrinsically linked to the practice of the medical profession. They can occur at several levels - prescription, drug preparation, dispensation, administration, and subsequent use of the drug by the patient. Nurses play an important role in the process of the drug administration in a hospital setting. Because of the occurrenceof medication errors and the consequent inability to achieve desired health outcomes, efforts are nowadays made to detect and minimize them. The aim of this study was to detect and analyze medication errors occurring during drug administration by nurses in a healthcare facility in South Bohemia. Methodology: The study is a part of a multi-year project involving the Faculty of Pharmacy of Charles University. The methodology is based on an observational study. The data collection took place in April 2022. Three hospital wards were assigned for the observation, where morning, midday and evening drug administration was monitored for three consecutive days. Data were recorded on a pre- generated form based on the...
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Analysis of drug administration by nurses in health facility XII
Gröszlová, Anna ; Doseděl, Martin (advisor) ; Malý, Josef (referee)
ANALYSIS OF DRUG ADMINISTRATION BY NURSES IN HEALTH FACILITY XII Author: Anna Gröszlová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Introduction: Medication administration in healthcare facilities significantly affects patient's safety. Observing and analyzing this process provide information about medication administration errors and the factors influencing them. As a result of observational findings, we can create interventions to improve the administration process. Aim: The aim of this work was to describe and analyze medication administration errors in a healthcare facility. Methods: The direct observation method was used for observation. Data collection took place in three departments (surgery, neurology, follow-up care) in 2021 and 2022. In both years, collection took place in each department on 3 consecutive days. Morning, midday and evening medication administration was monitored. An electronic database was used for recording. Data evaluation was done in Microsoft Excel and data from 2021 and 2022 were analyzed together. Nurse's work practices and medication errors were evaluated. Results: In total, 1160 drug administrations to 114 patients were observed. The largest number of...
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